17-Hydroxy-7β-(hydroxyMethyl)-15β,16β-Methylene-17α-pregn-3,5(6)-diene-21-carboxylic Acid, -Lactone

17-Hydroxy-7β-(hydroxyMethyl)-15β,16β-Methylene-17α-pregn-3,5(6)-diene-21-carboxylic Acid, -Lactone - Names and Identifiers

Name	Drospirenone
Synonyms	6b,7b Drosporenone Drospirenone dihydrospirorenone Drospirenone (USP32) Drospirenone(Dihydrospirorenone) 15b,16b-dimethylen-3-oxo-17a-pregn-4-ene-21,17-carbolactone 7β-(HydroxyMethyl)-15β,16β-Methylene-17α-pregn-3,5(6)-diene-21,17-carbolactone 17-Hydroxy-7β-(hydroxyMethyl)-15β,16β-Methylene-17α-pregn-3,5(6)-diene-21-carboxylic Acid, -Lactone (1aR,5aR,5bS,7aS,8S,8aS,9aS,9bS,9cR,9dR)-5a,7a-dimethyl-1,1a,5,5a,5b,6,7,7a,8a,9,9a,9b,9c,9d-tetradecahydro-3'H-spiro[cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthrene-8,2'-furan]-3,5'(4H,4'H)-dione
CAS	67392-87-4
EINECS	266-679-2
InChI	InChI=1/C24H30O3/c1-22-6-3-12(25)9-17(22)13-10-14(13)20-16(22)4-7-23(2)21(20)15-11-18(15)24(23)8-5-19(26)27-24/h9,13-16,18,20-21H,3-8,10-11H2,1-2H3/t13-,14+,15-,16+,18+,20-,21+,22-,23+,24+/m1/s1

17-Hydroxy-7β-(hydroxyMethyl)-15β,16β-Methylene-17α-pregn-3,5(6)-diene-21-carboxylic Acid, -Lactone - Physico-chemical Properties

Molecular Formula	C24H30O3
Molar Mass	366.5
Density	1.26±0.1 g/cm3(Predicted)
Melting Point	196-200°C
Boling Point	552.2±50.0 °C(Predicted)
Specific Rotation(α)	-180 º (c=0.5, chloroform)
Flash Point	241.6°C
Solubility	DMSO: ≥15
Vapor Presure	3.07E-12mmHg at 25°C
Appearance	powder
Color	white to tan
Storage Condition	2-8°C
Refractive Index	1.61
Physical and Chemical Properties	Melting Point: 196-200°C alpha: -180° (c=0.5, chloroform)

17-Hydroxy-7β-(hydroxyMethyl)-15β,16β-Methylene-17α-pregn-3,5(6)-diene-21-carboxylic Acid, -Lactone - Risk and Safety

Hazard Symbols	T - Toxic
Risk Codes	60 - May impair fertility
Safety Description	36/37 - Wear suitable protective clothing and gloves.
WGK Germany	3
RTECS	WH1299000
HS Code	2937230000

17-Hydroxy-7β-(hydroxyMethyl)-15β,16β-Methylene-17α-pregn-3,5(6)-diene-21-carboxylic Acid, -Lactone - Reference

Reference

1. [IF=7.514] Suo Decheng et al."Trace analysis of progesterone and 21 progestins in milk by ultra-performance liquid chromatography coupled with high-field quadrupole-orbitrap high-resolution mass spectrometry."Food Chem. 2021 Nov;361:130115

17-Hydroxy-7β-(hydroxyMethyl)-15β,16β-Methylene-17α-pregn-3,5(6)-diene-21-carboxylic Acid, -Lactone - Reference Information

natural progestogen	currently the only progestogen with similar properties to natural progesterone, completely different from the structure of progesterone contained in traditional oral contraceptives, it is closer to the natural progesterone. Drospirenone in addition to anti-androgen effect, but also has anti-mineralocorticoid effect, can prevent sodium retention in the body. Not only has excellent contraceptive effect, but also has many positive effects on women's physical health. For example, reduce acne, make the skin more smooth, effective weight control, etc.
side effects on human estrogen	drospirenone is a new synthetic progestogen designed to mimic the effects of progesterone, it is a progestogen with the pharmacological properties closest to natural progesterone, which has the unique advantages of anti-mineralocorticoid and anti-androgen activity. It appears as a form of a hormone that controls fertility. By Mimicking progesterone, it increases hormone levels and reduces the risk of pregnancy. Therefore, it is promoted as an effective contraceptive measure by the market. Unfortunately, since entering the market, Drospirenone has shown a negative effect on female estrogens. The combination of these two hormones can adversely affect the health of some people. when drospirenone reacts with estrogen, it can cause blood thickening in the body. It seems that this is a small problem, but blood clotting can lead to thrombosis. These blood clots form in blood vessels that block the flow of blood and even directly block the heart, brain, lungs and other vital organs. Blood clots interfere with the heart receiving blood and can cause a heart attack. If it affects blood flow to the brain, it causes a stroke. any woman who takes drospirenone will have the possibility of side effects, but people with obesity, diabetes, smoking, depression, hypertension who take drospirenone-containing contraceptives are more likely to cause thrombosis.
biological activity	Drospirenone (ZK 3059) is a synthetic progestogen that is an analog of Spironolactone.
Target	Value
toxic substance data	information provided by: pubchem.ncbi.nlm.nih.gov (external link)

Last Update：2024-04-09 21:04:16

17-Hydroxy-7β-(hydroxyMethyl)-15β,16β-Methylene-17α-pregn-3,5(6)-diene-21-carboxylic Acid, -Lactone

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17-Hydroxy-7β-(hydroxyMethyl)-15β,16β-Methylene-17α-pregn-3,5(6)-diene-21-carboxylic Acid, -Lactone

Drospirenone

CAS: 67392-87-4

Molecular Formula: C24H30O3

17-Hydroxy-7β-(hydroxyMethyl)-15β,16β-Methylene-17α-pregn-3,5(6)-diene-21-carboxylic Acid, -Lactone - Names and Identifiers

17-Hydroxy-7β-(hydroxyMethyl)-15β,16β-Methylene-17α-pregn-3,5(6)-diene-21-carboxylic Acid, -Lactone - Physico-chemical Properties

17-Hydroxy-7β-(hydroxyMethyl)-15β,16β-Methylene-17α-pregn-3,5(6)-diene-21-carboxylic Acid, -Lactone - Risk and Safety

17-Hydroxy-7β-(hydroxyMethyl)-15β,16β-Methylene-17α-pregn-3,5(6)-diene-21-carboxylic Acid, -Lactone - Reference

17-Hydroxy-7β-(hydroxyMethyl)-15β,16β-Methylene-17α-pregn-3,5(6)-diene-21-carboxylic Acid, -Lactone - Reference Information

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Drospirenone

CAS: 67392-87-4

Molecular Formula: C24H30O3

17-Hydroxy-7β-(hydroxyMethyl)-15β,16β-Methylene-17α-pregn-3,5(6)-diene-21-carboxylic Acid, -Lactone - Names and Identifiers

17-Hydroxy-7β-(hydroxyMethyl)-15β,16β-Methylene-17α-pregn-3,5(6)-diene-21-carboxylic Acid, -Lactone - Physico-chemical Properties

17-Hydroxy-7β-(hydroxyMethyl)-15β,16β-Methylene-17α-pregn-3,5(6)-diene-21-carboxylic Acid, -Lactone - Risk and Safety

17-Hydroxy-7β-(hydroxyMethyl)-15β,16β-Methylene-17α-pregn-3,5(6)-diene-21-carboxylic Acid, -Lactone - Reference

17-Hydroxy-7β-(hydroxyMethyl)-15β,16β-Methylene-17α-pregn-3,5(6)-diene-21-carboxylic Acid, -Lactone - Reference Information

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17-Hydroxy-7β-(hydroxyMethyl)-15β,16β-Methylene-17α-pregn-3,5(6)-diene-21-carboxylic Acid, -Lactone